#113 - Meet The Neuroscientist Decoding Your Bodies Cannabis System

Dr. Matt Hill is one of the world’s leading cannabis
neuroscientists, former president of the International
Cannabinoid Research Society, and a researcher with over 21,000
citations studying how the endocannabinoid system regulates the
brain and body.Cannabis affects different people in completely
opposite ways — calming one person while causing crippling
anxiety in another — and Hill explains why the biology makes this
inevitable, why both sides of the cannabis debate are getting it
wrong, and why legalisation in Canada accidentally destroyed the
very research that could have answered our biggest
questions.Expect to learn why CB1 is the most widely distributed
receptor in the brain yet almost nobody has heard of it, how
endocannabinoids work backwards across the synapse unlike any
other signalling system, why low-dose THC calms the amygdala but
high-dose THC causes paranoia and anxiety, why women get higher
than men on the same dose of cannabis due to a liver enzyme
difference, why only a third of people genuinely benefit from
medical cannabis while a third get nothing, how cannabis triggers
schizophrenia in genetically vulnerable people without actually
causing the disease, why Canadian legalisation killed cannabis
clinical trials through a bureaucratic GMP-versus-GPP standoff,
what the real cardiovascular risks of chronic cannabis use are,
why cannabis users paradoxically have lower obesity rates, and
much more…Timestamps: 00:00 Trailer02:00 Dr. Matt Hill — Cannabis
Neuroscientist02:25 The Endocannabinoid System: Your Body’s Own
Cannabis04:23 Every Biological Function It Controls06:30 The Most
Distributed Receptor Nobody’s Heard Of07:20 Why Cannabis Science
Is So Politically Toxic09:35 Both Sides Are Wrong: The Three
Blind Men Problem10:23 The Frustrating Polarity of the Cannabis
Debate12:37 Your Personal Experience Doesn’t Generalise16:25 Why
Cannabis Feels Like a Different Drug for Different People17:52
Retrograde Signalling: How Cannabis Works Backwards20:08 Low Dose
Calms, High Dose Causes Paranoia — Here’s Why22:24 Women Produce
More 11-Hydroxy-THC Than Men25:52 Why Receptor Distribution Makes
Cannabis Unpredictable27:11 The PET Scan Problem: Why We Can’t
Map Your Receptors29:04 Why Cannabis Companies Don’t Fund Real
Research31:25 How Legalisation Accidentally Killed Cannabis
Science34:46 The GMP vs GPP Bureaucratic Disaster38:09 David
Nutt: Drug Policy Driven by Politics Not Science43:01 Why You
Can’t Standardise Cannabis Dosing Like Alcohol49:44 The Three
Thirds Rule: Benefit, Side Effects, or Nothing53:05 The Best
Evidence: Where Cannabis Actually Works53:36 Schizophrenia Risk —
It’s a Trigger, Not a Cause55:52 Cardiovascular Risk: The
Under-Discussed Real Danger57:02 Does Exercise Cancel Out
Cannabis Heart Risk?58:14 The Obesity Paradox: Why Cannabis Users
Are Thinner01:01:03 Chronic Pain, MS, Epilepsy and PTSD — The
Medical Evidence01:03:18 Final Thoughts and a Plea for
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