#136 - Denis Noble: Neo-Darwinism, Michael Levin & Why The Last 70 Years of Genetics Is Wrong

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Denis Noble is the physiologist who built the first computer
model of the heart in 1960 — and has spent the sixty years since
using it to dismantle the gene-centric view of life that
dominates modern biology. He took Richard Dawkins's Selfish Gene
and rewrote its most famous passage word for word in reverse —
and every single experiment still fits.Expect to learn why the
central dogma of molecular biology is provably wrong, how your
immune system rewrites its own DNA to fight off new viruses, why
the peppered moth story in every biology textbook turns out to be
false, what happened when Denis told Richard Dawkins "Lamarck is
back" to his face, why a cell corrects roughly 800,000 DNA
replication errors before it's allowed to divide, how epigenetic
inheritance can persist indefinitely if the environment stays
changed, whether plants might have a form of experience, and
where exactly agency ends and pure chemistry begins.





Timestamps


0:00:00 Trailer


0:02:27 Meet The Man Who Modeled The Heart By Hand


0:04:43 Why The Central Dogma Of Biology Is Wrong


0:06:39 The 1866 Split Between Darwin And Wallace


0:09:02 The Infinite Monkey Theorem, Tested For Real


0:17:30 The Peppered Moth Myth Textbooks Still Teach


0:20:19 The Nobel Laureate Textbooks Forgot To Cite


0:22:53 Telling Richard Dawkins "Lamarck Is Back"


0:27:43 Was Lamarck's Giraffe Neck Story Actually Right?


0:29:40 How Your Body Talks To Your DNA


0:38:17 A New Species Evolved In Two Generations


0:44:18 So What's Actually Controversial Here?


0:48:09 Cellular Agency: When Cells Act Like Organisms


0:53:04 Steelmanning The Case Against Cellular Agency


0:55:05 The 17th-Century Prediction That Proved Purpose Works


1:04:20 Your Cells Correct 800,000 DNA Errors Per Division


1:13:14 Life Lives On The Edge Of Order And Chaos


1:15:27 Do Plants Have Experience?


1:27:31 How Does Consciousness Fit Into Systems Biology?......





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GS Episodes Mentioned


Michael Levin — Meet the Scientist Creating New Forms of
Synthetic Life! Dr Michael Levin:
https://www.youtube.com/watch?v=LTBZRVKUwyM


Philip Ball — Philip Ball: "Biology Is Infinitely Weirder Than We
Thought": https://www.youtube.com/watch?v=9SseGx0R0fY





Guest Links


Oxford Faculty Page:
https://www.dpag.ox.ac.uk/team/denis-noblePersonal Website:
https://www.denisnoble.com


Google Scholar:
https://scholar.google.com/citations?user=J6kLmsIAAAAJ&hl=en


Understanding Living Systems (Book):
https://www.amazon.com/Understanding-Living-Systems-Life/dp/1009277367


The Third Way of Evolution:
https://www.thethirdwayofevolution.com/people/view/denis-noble