Beschreibung
vor 19 Jahren
Endothelial cell survival is indispensable to maintain endothelial
integrity and initiate new vessel formation. We investigated the
role of SHP-2 in proliferation, survival and sprouting of human
microvascular- and umbilical vein endothelial cells (HMEC, HUVEC)
using antisense oligonucleotides (AS-ODN) and a pharmacological
SHP-2 inhibitor (PtpI IV). Knock-down of SHP-2 decreased bFGF and
PDGF dependent endothelial cell proliferation (p
integrity and initiate new vessel formation. We investigated the
role of SHP-2 in proliferation, survival and sprouting of human
microvascular- and umbilical vein endothelial cells (HMEC, HUVEC)
using antisense oligonucleotides (AS-ODN) and a pharmacological
SHP-2 inhibitor (PtpI IV). Knock-down of SHP-2 decreased bFGF and
PDGF dependent endothelial cell proliferation (p
Weitere Episoden
vor 18 Jahren
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