Evolution des programmierten Zelltods
Beschreibung
vor 20 Jahren
The simple metazoan Hydra does posses two genes for caspases:
Caspase 3A and caspase 3B. We generated antibodies against these
caspases. By immunofluorescence staining and cell fractionation we
demonstrated that both caspases are localized in mitochondria in
vivo.Caspase 3A is a constitutively active enzyme independent of
PCD. After induction of apoptosis caspase 3B translocates from the
mitochondria to the cytoplasm and is activated. Activity of 3B is
DEVD-specific.
Caspase 3A and caspase 3B. We generated antibodies against these
caspases. By immunofluorescence staining and cell fractionation we
demonstrated that both caspases are localized in mitochondria in
vivo.Caspase 3A is a constitutively active enzyme independent of
PCD. After induction of apoptosis caspase 3B translocates from the
mitochondria to the cytoplasm and is activated. Activity of 3B is
DEVD-specific.
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