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Medizin - Open Access LMU - Teil 05/22 Podcast
Relation of hyperlipidemia in serum and loss of high density lipoproteins in urine in the nephrotic syndrome

Relation of hyperlipidemia in serum and loss of high density lipoproteins in urine in the nephrotic syndrome

Medizin - Open Access LMU - Teil 05/22 vor 39 Jahren

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The mechanism leading to hyperlipidemia in the nephrotic syndrome
is not fully understood but may be related in part to loss of high
density lipoproteins in the urine of patients with nephrosis. To
prove this hypothesis, we compared serum lipoprotein profiles with
the excretion of high density lipoproteins in urine in 19 nephrotic
patients. Serum cholesterol ranged from 19–152 (median value 45)
mg/dl in very low density lipoproteins (VLDL), from 130–443 (median
186) mg/dl in low density lipoproteins (LDL) and from 19–64 (median
33) mg/dl in high density lipoproteins (HDL). Hyperlipoproteinemia
was found in 17 patients, which was classified as phenotype IIa
(Fredrickson) in 2, as phenotype IIb in 9 and as phenotype IV in 6
subjects. Two patients showed normal lipoprotein patterns. VLDL-
and LDL-cholesterol were not found in detectable amounts in urine,
whereas HDL-cholesterol was measured in low concentrations from
0.1–8.3 mg/24 h in all samples. There was no correlation between
serum HDL-cholesterol and urinary HDL-cholesterol, but a positive
correlation between serum LDL-cholesterol and urinary
HDL-cholesterol (r= +0.54, p < 0.05). However, the total amount
of the daily urinary loss of HDL (