Symptomatik und Mediatorfreisetzung nach nasaler Allergenprovokation

This examination is an approach of the allergic late phase reaction
via quality of life, acoustic rhinometry, and determination of ECP,
IL-5, IL-8, MCP-1, MCP-3, RANTES, sVCAM-1, and LTC4 in nasal
secretions. It describes and discusses changes in subjective and
objective parameters over a time period of eight hours following
nasal allergen application. Data obtained from a clinical and an
experimental part is analyzed and statistically compared in
reference to the existence of an early and late phase allergic
reaction. Results are discussed under consideration of a possible
neurological participation in the occurrence and persistence of the
allergic inflammatory process.