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  3. Thriving Minds with Alberto Zandi Podcast
  4. Cambridge Weight Loss Scientist: Your Brain Fights Weight Loss! Why Diets Are So Hard To Stick To, The Truth About Calories & How To Keep Weight Off | Prof Giles Yeo
Professor Giles Yeo MBE has spent 30 years studying one of the
most misunderstood questions in health: why some people feel
hungrier, gain weight more easily and find it much harder to keep
weight off than others.

He is Professor of Molecular Neuroendocrinology at the University
of Cambridge, where his research focuses on how our genes,
hormones and brain control appetite and body weight. In 2026, he
was elected a Fellow of the Academy of Medical Sciences for his
internationally recognised work on the genetics and neuroscience
of obesity.

And one of his central messages challenges the way many of us
think about weight.

Two people can be faced with exactly the same food, but
experience very different levels of hunger, fullness and reward.
Your biology does not remove personal responsibility, but it can
dramatically change how difficult the same decision feels.

In this episode, you will learn:

• Why your brain actively fights weight loss, increasing hunger
and changing your metabolism when you lose weight

• Why two people can eat the same food but experience completely
different levels of appetite and food noise

• What calories fail to tell you about food, and why protein,
fibre and ultra-processed foods affect your body differently

• How Ozempic and other GLP-1 drugs actually work, why weight
often returns after stopping them, and the risks people need to
understand

• Giles's simple 16:30:5 framework for eating enough protein and
fibre to lose weight while reducing free sugar without obsessing
over individual meals

Giles also speaks personally about his son's experience with
obesity and GLP-1 medication, and admits that even after spending
his career studying obesity, he still had to fight the human
instinct to blame.

Follow Prof Giles Yeo:

⁠https://uk.linkedin.com/in/giles-yeo-2062969

⁠⁠https://www.instagram.com/gilesyeo/

⁠⁠https://www.facebook.com/giles.yeo/⁠

#ThrivingMinds #AlbertoZandi #GilesYeo #Neuroscience
#AppetiteScience #BrainHealth #WeightLoss #HungerHormones
#NutritionScience #ObesityResearch #HealthPodcast
#MetabolicHealth #FoodScience

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„Cambridge Weight Loss Scientist: Your Brain Fights Weight Loss! Why Diets Are So Hard To Stick To, The Truth About Calories & How To Keep Weight Off | Prof Giles Yeo“

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