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  3. The Ultimate Human with Gary Brecka Podcast
  4. 306. The Alzheimer's Drug With a 25% Brain Bleed Risk - Dr. David Perlmutter
You might think Alzheimer's starts in your 70s. Dr. David
Perlmutter explains why it begins decades earlier, and how the
p-tau 217 blood test flags risk long before symptoms appear. Gary
Brecka and Dr. Perlmutter break down microglia, insulin resistance,
pre-diabetes, APOE4, homocysteine, vitamin D, creatine and sleep,
plus what the POINTER study showed about cognitive decline in
metabolically compromised adults. CLICK HERE TO BECOME GARY’S VIP!:
https://bit.ly/4ai0Xwg Get Dr. David Perlmutter’s book, “Brain
Defenders”: https://bit.ly/4xvoYtY Listen to Dr. David Perlmutter
on all your favorite platforms! YouTube:
https://bit.ly/46rZjan  Spotify: https://bit.ly/4dxPdZl 
Apple Podcasts: https://bit.ly/4dBz19u  Connect with Dr. David
Perlmutter Website: https://bit.ly/4yEhBBk  YouTube:
https://bit.ly/46rZjan  Instagram:
https://bit.ly/3VgElZH  Facebook: https://bit.ly/4xvTC6v 
TikTok: https://bit.ly/4xXDcEM  X:
https://bit.ly/4xxJdal  LinkedIn: https://bit.ly/4yfpNIF 
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https://bit.ly/3PEAJuG Timestamps 00:00 - Intro of the Show 01:33 -
Grain Brain and ultra-processed carbohydrates 03:26 - Pre-diabetes
decades before any symptoms 08:03 - Type 3 diabetes and insulin in
the brain 11:48 - The fasting insulin level to target 14:08 -
Immunometabolism and your microglial cells 16:12 - APOE4 as
predisposition, not destiny 19:25 - Inflammation from the gut,
mouth and air 25:50 - Aerobic vs resistance training for the brain
30:04 - Sarcopenia, myokines and BDNF 34:44 - Mitochondria and the
TSPO brain scan 40:11 - The Tanzi, Ornish and POINTER trials 46:31
- Beta-amyloid drugs and the Cochrane data 55:00 - Sleep, the
glymphatic system and insulin 58:25 - Creatine dosing and the
creatinine confusion 1:03:52 - Vitamin D, VDR polymorphisms and tau
1:09:35 - Fish oil, DHA and the omega-3 study 1:12:48 -
Homocysteine, B complex and MTHFR 1:18:43 - Red light, RNS60 and
mitochondrial transplant 1:27:11 - Isolation, cortisol and oxytocin
1:32:58 - What it means to be an ultimate human Disclaimer: This
podcast is for informational purposes only and does not provide
medical advice. It is not intended for diagnosing or treating any
health condition. Always consult a licensed healthcare professional
before making health or wellness decisions. Gary Brecka is the
owner of Ultimate Human, LLC which operates The Ultimate Human
podcast and promotes certain third-party products used by Gary
Brecka in his personal health and wellness protocols and daily life
and for which Ultimate Human LLC and / or Gary Brecka directly or
indirectly holds an economic interest or receives
compensation.  Accordingly, statements made by Gary Brecka and
others (including on The Ultimate Human podcast) may be considered
promotional in nature. Learn more about your ad choices. Visit
megaphone.fm/adchoices
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„306. The Alzheimer's Drug With a 25% Brain Bleed Risk - Dr. David Perlmutter“

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