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Say Goodbye to Booster Shots – New Vaccine Technology for Long-Lasting Protection

Say Goodbye to Booster Shots – New Vaccine Technology for Long-Lasting Protection

InFact - Der HZI-Podcast. Wissenschaft, die ansteckt. vor 17 Stunden

with Dr. Henning Jacobsen, Research Group “Viral Immunology” & Casper Silvis, Research Group "Personalised Immunotherapy" at the Helmholtz Centre for Infection Research (HZI)

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27:39

A single vaccination that provides protection for many years – so
far, this has rarely been possible with vaccines against
respiratory pathogens. While many vaccines offer long-term
protection against severe illness, protection against rapidly
mutating pathogens—such as influenza viruses or SARS-CoV-2—wanes
quickly. Regular booster shots are therefore often necessary. Dr.
Henning Jacobsen and Casper Silvis from the Helmholtz Centre for
Infection Research want to change that. As part of the ENDURIVAC
project, they are developing a vaccine technology designed to
provide long-lasting protection after just one dose. Their vector
is the murine cytomegalovirus: It cannot make humans ill but is
intended to continuously train the immune system using selected
antigens. In this episode of InFact, host Julia Demann talks to
them about how the technology works, why it is initially being used
to develop a vaccine against RSV – and whether booster shots could
largely become unnecessary in the future.