In this episode of Current Vet, Dr Lottie talks
about Jaagsiekte, also known as Ovine
Pulmonary Adenocarcinoma (OPA)
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Timeline:
00:00 Intro
00:56 Case
03:48 Aetiology & Pathogenesis
06:25 Clinical Signs
08:28 Diagnosis
12:34 Treatment
16:53 Current Research
18:09 Key Points
19:44 Outro
Recommended Reading
World Organisation for Animal Health (WOAH).
(2023). Ovine Pulmonary Adenocarcinoma (Jaagsiekte).
In Manual of Diagnostic Tests and Vaccines for Terrestrial
Animals. WOAH PDF
Cousens, C., et al. (2024). Tracking Ovine
Pulmonary Adenocarcinoma Development Using an Experimental
Jaagsiekte Sheep Retrovirus Infection Model. Genes, 15(8),
1019. https://doi.org/10.3390/genes15081019
O’Conor, K. & Chase, C. C. L., (2020). 5-Minute
Veterinary Consult: Ruminant, 2nd edn. Wiley-Blackwell. pp.
582-583. Constable, P. D., Hinchcliff, K. W., Done, S. H. &
Grünberg, W., (2021). Veterinary Medicine: A Textbook of the
Diseases of Cattle, Horses, Sheep, Pigs and Goats, 11th edn.
Elsevier, pp. 977–979.
References
Toma, C. et al. (2025). Overexpression of IL-6 and STAT3 may
provide new insights into ovine pulmonary adenocarcinoma
development. BMC Veterinary Research, 21, 29.
Cousens, C., et al. (2024). Tracking Ovine Pulmonary
Adenocarcinoma Development Using an Experimental Jaagsiekte Sheep
Retrovirus Infection Model*.* Genes, 15(8), 1019.
https://doi.org/10.3390/genes15081019.
World Organisation for Animal Health (WOAH). (2023) Ovine
Pulmonary Adenocarcinoma (Jaagsiekte). In: Manual of Diagnostic
Tests and Vaccines for Terrestrial Animals. WOAH, Paris.
Available at:
https://www.woah.org/fileadmin/Home/fr/Health_standards/tahm/3.07.08_OPA.pdf
O’Conor, K. & Chase, C. C. L., (2020). 5-Minute
Veterinary Consult: Ruminant, 2nd edn. Wiley-Blackwell. pp.
582-583.
Constable, P. D., Hinchcliff, K. W., Done, S. H. &
Grünberg, W., (2021). Veterinary Medicine: A Textbook of the
Diseases of Cattle, Horses, Sheep, Pigs and Goats, 11th edn.
Elsevier, pp. 977–979.
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