TRR179 - New avenues for vaccines and cancer immunotherapies

Chronic infections cause long-term changes in key immune
cells. T-helper cells suppress their immune function to ensure
their survival.


T-helper cells, scientifically known as CD4⁺ T cells, control key
processes in our immune system. They detect signs of pathogens
and relay signals to other immune cells. In this way, they help B
cells produce antibodies and support T killer cells in fighting
infected cells. Researchers at the Medical Center – University of
Freiburg have now investigated how these immune cells change
under prolonged stress during chronic infections. Using chronic
hepatitis C infection as an example, the team demonstrated that T
helper cells shift their focus: they regulate the immune response
less vigorously in order to ensure their own survival. This helps
to better understand the course of chronic infections and opens
up avenues for new therapies. The findings were published on
April 1, 2026, in the journal Immunity.


Original title of the publication: Acute and
chronic infections drive distinct trajectories in human memory
CD4+ T cell formation
DOI: 10.1016/j.immuni.2026.03.008
Link to the study:
https://doi.org/10.1016/j.immuni.2026.03.008