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AI Cancer Vaccines, Strange Fish, Ketamine, and Ancient Life (EP. 34)

AI Cancer Vaccines, Strange Fish, Ketamine, and Ancient Life (EP. 34)

From First Principles vor 5 Monaten

0:00

44:58

Hosted by Lester Nare and Krishna
Choudhary, this episode is a fast-moving science rundown
covering four remarkable stories from across AI, genetics,
neuroscience, and paleontology. We dig into the story of a
machine learning engineer who used AI tools to help design a
personalized cancer vaccine for his dog, explore how an
all-female fish species has survived far longer than evolutionary
theory would predict, unpack new brain-scan evidence for how
ketamine may rapidly relieve severe depression, and look at new
research suggesting life rebounded shockingly fast after the
asteroid that killed the dinosaurs.

Summary

AI and personalized medicine — a striking case
study in how AI tools may help accelerate highly customized
treatments, starting with a rescue dog named Rosie.

Evolution gets weird — the Amazon molly fish
appears to challenge the usual assumptions about why asexual
reproduction should fail over long time scales.

Why ketamine works so fast — new PET imaging
research points to brain-region-specific changes in AMPA
receptors in treatment-resistant depression.

Life after catastrophe — microscopic plankton
may have evolved into new species within just a few thousand
years after the Chicxulub impact.

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Show Notes

AI-designed dog cancer vaccine story

https://finance.yahoo.com/news/mans-dog-riddled-tumors-dying-210500037.html?guccounter=1

Amazon molly / gene conversion paper

https://www.nature.com/articles/s41586-026-10180-9

Ketamine / AMPA receptor PET imaging paper

https://www.nature.com/articles/s41380-026-03510-w

Post-asteroid plankton recovery paper

https://www.yokohama-cu.ac.jp/english/news/20260306takahashi.html