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BiocompCHATibility Podcast
Oh No, Another Failed Cyto

Oh No, Another Failed Cyto

BiocompCHATibility vor 5 Jahren

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35:37

Podcast

BiocompCHATibility

38 Episoden

A podcast dedicated to medical device biocompatibility

Wissenschaft Gesundheit & Fitness

Podcast aneignen

In this episode, our guests are joined my NAMSA’s Melissa Cadaret
to discuss the ever-confusing cytotoxicity failure.
Manufacturers can have more questions created when encountering
an unexpected cytotoxicity result and these podcast experts have
seen thousands of various cytotoxicity results. The
information provided from a cytotoxicity test can be useful and
stressful, so what do manufacturers need to know to navigate the
cyto failure, whether expected or unexpected.

“I would say we generally see some type of cytotoxicity failure
weekly.” –Melissa Cadaret

“Cytotoxicity is not really an end point. It’s a screen.” –
Sheri Krajewski-Bibins

“It is what it is and it is what it’s not.” – Don Pohl

“It’s the only biological effect listed as an overall screen for
biocompatibility.” – Don Pohl

“Things like copper, and antimicrobials really wreak havoc and
contribute to a lot of cytotoxicity failures. Some of your
residues from your cleaning and in processing aspect are also a
huge culprit.” Melissa Cadaret

“It might have been expected. You can get pretty good at
predicting cytotoxicity.” – Don Pohl

Discussion points include:

What does it mean when one receives a failed cyto
result

What is the useful information you can gather from a
cytotoxicity test

What typical materials and devices may have problems with a
cytotoxicity test

What to do if you know your material is going to fail cyto