podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 20/22 Podcast
  4. Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer.
The transcription factor SOX2 (3q26.3-q27) is an embryonic stem
cell factor contributing to the induction of pluripotency in
terminally differentiated somatic cells. Recently, amplification of
the SOX2 gene locus has been described in squamous cell carcinoma
(SCC) of different organ sites. Aim of this study was to
investigate amplification and expression status of SOX2 in
sinonasal carcinomas and to correlate the results with
clinico-pathological data. A total of 119 primary tumor samples
from the sinonasal region were assessed by fluorescence in-situ
hybridization and immunohistochemistry for SOX2 gene amplification
and protein expression, respectively. Of these, 59 were SSCs, 18
sinonasal undifferentiated carcinomas (SNUC), 10 carcinomas
associated with an inverted papilloma (INVC), 19 adenocarcinomas
(AD) and 13 adenoid cystic carcinomas (ACC). SOX2 amplifications
were found in subsets of SCCs (37.5%), SNUCs (35.3%), INVCs (37.5%)
and ADs (8.3%) but not in ACCs. SOX2 amplification resulted in
increased protein expression. Patients with SOX2-amplified
sinonasal carcinomas showed a significantly higher rate of tumor
recurrences than SOX2 non-amplified tumors. This is the first study
assessing SOX2 amplification and expression in a large cohort of
sinonasal carcinomas. As opposed to AD and ACC, SOX2 amplifications
were detected in more than 1/3 of all SCCs, SNUCs and INVCs. We
therefore suggest that SNUCs are molecularly closely related to
SCCs and INVCs and that these entities represent a subgroup of
sinonasal carcinomas relying on SOX2 acquisition during
oncogenesis. SOX2 amplification appears to identify sinonasal
carcinomas that are more likely to relapse after primary therapy,
suggesting that these patients might benefit from a more aggressive
therapy regime.

Weitere Episoden

Persistent nasal methicillin-resistant staphylococcus aureus carriage in hemodialysis outpatients: a predictor of worse outcome

Persistent nasal methicillin-resistant staphylococcus aureus carriage in hemodialysis outpatients: a predictor of worse outcome

vor 13 Jahren
Dose-volumetric parameters and prediction of severe acute esophagitis in patients with locally-advanced non small-cell lung cancer treated with neoadjuvant concurrent hyperfractionated-accelerated chemoradiotherapy

Dose-volumetric parameters and prediction of severe acute esophagitis in patients with locally-advanced non small-cell lung cancer treated with neoadjuvant concurrent hyperfractionated-accelerated chemoradiotherapy

vor 13 Jahren
Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set

Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set

vor 13 Jahren
Genome-wide linkage analysis of congenital heart defects using MOD score analysis identifies two novel loci

Genome-wide linkage analysis of congenital heart defects using MOD score analysis identifies two novel loci

vor 13 Jahren
Comparison of symptomatic and asymptomatic atherosclerotic carotid plaques using parallel imaging and 3 T black-blood in vivo CMR

Comparison of symptomatic and asymptomatic atherosclerotic carotid plaques using parallel imaging and 3 T black-blood in vivo CMR

vor 13 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„Sex determining region Y-box 2 (SOX2) amplification is an independent indicator of disease recurrence in sinonasal cancer.“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz