Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms ~ Medizin - Open Access LMU

Therapy related myeloid neoplasms (t-MNs) are complex diseases
originating from an interplay between exogenous toxicities and a
susceptible organism. It has been hypothesised that in a subset of
cases t-MNs develop in the context of hereditary cancer
predisposition syndromes.

Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms

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