podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 20/22 Podcast
  4. Computational identification of phospho-tyrosine sub-networks related to acanthocyte generation in neuroacanthocytosis
Acanthocytes, abnormal thorny red blood cells (RBC), are one of the
biological hallmarks of neuroacanthocytosis syndromes (NA), a group
of rare hereditary neurodegenerative disorders. Since RBCs are
easily accessible, the study of acanthocytes in NA may provide
insights into potential mechanisms of neurodegeneration. Previous
studies have shown that changes in RBC membrane protein
phosphorylation state affect RBC membrane mechanical stability and
morphology. Here, we coupled tyrosine-phosphoproteomic analysis to
topological network analysis. We aimed to predict signaling
sub-networks possibly involved in the generation of acanthocytes in
patients affected by the two core NA disorders, namely McLeod
syndrome (MLS, XK-related, Xk protein) and chorea-acanthocytosis
(ChAc, VPS13A-related, chorein protein). The experimentally
determined phosphoproteomic data-sets allowed us to relate the
subsequent network analysis to the pathogenetic background. To
reduce the network complexity, we combined several algorithms of
topological network analysis including cluster determination by
shortest path analysis, protein categorization based on centrality
indexes, along with annotation-based node filtering. We first
identified XK- and VPS13A-related protein-protein interaction
networks by identifying all the interactomic shortest paths linking
Xk and chorein to the corresponding set of proteins whose tyrosine
phosphorylation was altered in patients. These networks include the
most likely paths of functional influence of Xk and chorein on
phosphorylated proteins. We further refined the analysis by
extracting restricted sets of highly interacting signaling proteins
representing a common molecular background bridging the generation
of acanthocytes in MLS and ChAc. The final analysis pointed to a
novel, very restricted, signaling module of 14 highly
interconnected kinases, whose alteration is possibly involved in
generation of acanthocytes in MLS and ChAc

Weitere Episoden

Persistent nasal methicillin-resistant staphylococcus aureus carriage in hemodialysis outpatients: a predictor of worse outcome

Persistent nasal methicillin-resistant staphylococcus aureus carriage in hemodialysis outpatients: a predictor of worse outcome

vor 13 Jahren
Dose-volumetric parameters and prediction of severe acute esophagitis in patients with locally-advanced non small-cell lung cancer treated with neoadjuvant concurrent hyperfractionated-accelerated chemoradiotherapy

Dose-volumetric parameters and prediction of severe acute esophagitis in patients with locally-advanced non small-cell lung cancer treated with neoadjuvant concurrent hyperfractionated-accelerated chemoradiotherapy

vor 13 Jahren
Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set

Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set

vor 13 Jahren
Genome-wide linkage analysis of congenital heart defects using MOD score analysis identifies two novel loci

Genome-wide linkage analysis of congenital heart defects using MOD score analysis identifies two novel loci

vor 13 Jahren
Comparison of symptomatic and asymptomatic atherosclerotic carotid plaques using parallel imaging and 3 T black-blood in vivo CMR

Comparison of symptomatic and asymptomatic atherosclerotic carotid plaques using parallel imaging and 3 T black-blood in vivo CMR

vor 13 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„Computational identification of phospho-tyrosine sub-networks related to acanthocyte generation in neuroacanthocytosis“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz