podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 15/22 Podcast
  4. Intracapillary leucocyte accumulation as a novel antihaemorrhagic mechanism in acute pancreatitis in mice
Background: Pancreatic infiltration by leucocytes represents a
hallmark in acute pancreatitis. Although leucocytes play an active
role in the pathophysiology of this disease, the relation between
leucocyte activation, microvascular injury and haemorrhage has not
been adequately addressed.Methods: We investigated intrapancreatic
leucocyte migration, leucocyte extravasation and pancreatic
microperfusion in different models of oedematous and necrotising
acute pancreatitis in lys-EGFP-ki mice using fluorescent imaging
and time-lapse intravital microscopy.Results: In contrast to the
current paradigm of leucocyte recruitment, the initial event of
leucocyte activation in acute pancreatitis was represented through
a dose- and time-dependent occlusion of pancreatic capillaries by
intraluminally migrating leucocytes. Intracapillary leucocyte
accumulation (ILA) resulted in dense filling of almost all
capillaries close to the area of inflammation and preceded
transvenular leucocyte extravasation. ILA was also initiated by
isolated exposure of the pancreas to interleukin 8 or fMLP,
demonstrating the causal role of chemotactic stimuli in the
induction of ILA. The onset of intracapillary leucocyte
accumulation was strongly inhibited in LFA-1-/- and ICAM-1-/- mice,
but not in Mac-1-/- mice. Moreover, prevention of intracapillary
leucocyte accumulation led to the development of massive capillary
haemorrhages and transformed mild pancreatitis into lethal
haemorrhagic disease.Conclusions: ILA represents a novel protective
and potentially lifesaving mechanism of haemostasis in acute
pancreatitis. This process depends on expression of LFA-1 and
ICAM-1 and precedes the classical steps of the leucocyte
recruitment cascade.

Weitere Episoden

Report of the Working Group `Overall Blood Supply Strategy with Regard to Variant Creutzfeldt-Jakob Disease (vCJD)'

Report of the Working Group `Overall Blood Supply Strategy with Regard to Variant Creutzfeldt-Jakob Disease (vCJD)'

vor 17 Jahren
Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial

Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial

vor 17 Jahren
Guidelines for initiation of anti-tumour necrosis factor therapy in rheumatoid arthritis: similarities and differences across Europe.

Guidelines for initiation of anti-tumour necrosis factor therapy in rheumatoid arthritis: similarities and differences across Europe.

vor 17 Jahren
JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.

JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.

vor 17 Jahren
Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.

Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.

vor 17 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„Intracapillary leucocyte accumulation as a novel antihaemorrhagic mechanism in acute pancreatitis in mice“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz