CELL-SELEX: Novel perspectives of aptamer-based therapeutics

Aptamers, single stranded DNA or RNA molecules, generated by a
method called SELEX (systematic evolution of ligands by exponential
enrichment) have been widely used in various biomedical
applications. The newly developed Cell-SELEX (cell based-SELEX)
targeting whole living cells has raised great expectations for
cancer biology, -therapy and regenerative medicine. Combining
nanobiotechnology with aptamers, this technology opens the way to
more sophisticated applications in molecular diagnosis. This paper
gives a review of recent developments in SELEX technologies and new
applications of aptamers.