podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 15/22 Podcast
  4. Meta-analysis of randomized trials: Evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer
Background: Single-agent gemcitabine ( GEM) is a standard treatment
for advanced and metastatic pancreatic cancer. This study examines
the question whether GEM-based combination chemotherapy can further
improve treatment efficacy. Methods: A meta-analysis was performed
to evaluate randomized trials comparing GEM versus GEM+X ( X =
cytotoxic agent). Fifteen trials including 4465 patients were
eligible for an analysis of overall survival, the primary end-point
of this investigation. Results: The meta-analysis revealed a
significant survival benefit for GEM+X with a pooled hazard ratio (
HR) of 0.91 ( 95% CI: 0.85 - 0.97, p = 0.004). The overall test for
heterogeneity resulted in p = 0.82 ( I(2) = 0%). The analysis of
platinum-based combinations indicated a HR of 0.85 ( 95% CI: 0.76 -
0.96, p = 0.010), while for fluoropyrimidine-based combinations the
HR was 0.90 ( 95% CI: 0.81 - 0.99, p = 0.030). No risk reduction
was observed in the group of trials combining GEM with irinotecan,
exatecan or pemetrexed ( HR = 0.99). A meta-analysis of the trials
with adequate information on baseline performance status ( PS) was
performed in five trials with 1682 patients. This analysis
indicated that patients with a good PS had a marked survival
benefit when receiving combination chemotherapy ( HR = 0.76; 95%
CI: 0.67 - 0.87; p < 0.0001). By contrast, application of
combination chemotherapy to patients with an initially poor PS
appeared to be ineffective ( HR = 1.08; 95% CI: 0.90 - 1.29, p =
0.40). Conclusion: The meta-analysis of randomized trials indicated
a significant survival benefit when GEM was either combined with
platinum analogs or fluoropyrimidines. Based on a preliminary
subgroup analysis ( representing 38% of all patients included in
this meta-analysis), pancreatic cancer patients with a good PS
appear to benefit from GEM-based cytotoxic combinations, whereas
patients with a poor PS seem to have no survival benefit from
combination chemotherapy.

Weitere Episoden

Report of the Working Group `Overall Blood Supply Strategy with Regard to Variant Creutzfeldt-Jakob Disease (vCJD)'

Report of the Working Group `Overall Blood Supply Strategy with Regard to Variant Creutzfeldt-Jakob Disease (vCJD)'

vor 17 Jahren
Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial

Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial

vor 17 Jahren
Guidelines for initiation of anti-tumour necrosis factor therapy in rheumatoid arthritis: similarities and differences across Europe.

Guidelines for initiation of anti-tumour necrosis factor therapy in rheumatoid arthritis: similarities and differences across Europe.

vor 17 Jahren
JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.

JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.

vor 17 Jahren
Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.

Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.

vor 17 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„Meta-analysis of randomized trials: Evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz