podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 15/22 Podcast
  4. Alternative antibody for the detection of CA125 antigen: a European multicenter study for the evaluation of the analytical and clinical performance of the Access (R) OV Monitor assay on the UniCel (R) Dxl 800 Immunoassay System
Alternative antibody for the detection of CA125 antigen: a European multicenter study for the evaluation of the analytical and clinical performance of the Access (R) OV Monitor assay on the UniCel (R) Dxl 800 Immunoassay System

Alternative antibody for the detection of CA125 antigen: a European multicenter study for the evaluation of the analytical and clinical performance of the Access (R) OV Monitor assay on the UniCel (R) Dxl 800 Immunoassay System

Medizin - Open Access LMU - Teil 15/22 vor 18 Jahren
Zu Sammlung hinzufügen

Du hast noch keine Sammlungen.
Herunterladen (rechte Maustaste) Teilen Fundstellen Kommentare
0:00
0:00
Background: Cancer antigen CA125 is known as a valuable marker for
the management of ovarian cancer. Methods: The analytical and
clinical performance of the Access OV Monitor Immunoassay System
(Beckman Coulter) was evaluated at five different European sites
and compared with a reference system, defined as CA125 on the
Elecsys System (Roche Diagnostics). Results: Total imprecision
(%CV) of the OV Monitor ranged between 3.1% and 8.8%, and
inter-laboratory reproducibility between 4.7% and 5.0%. Linearity
upon dilution showed a mean recovery of 100% (SD+8.1%). Endogenous
interferents had no influence on OV Monitor levels (mean
recoveries: hemoglobin 107%, bilirubin 103%, triglycericles 103%).
There was no high-dose hook effect up to 27,193 kU/L. Clinical
performance investigated in sera from 1811 individuals showed a
good correlation between the Access OV Monitor and Elecsys CA125 (R
= 0.982, slope = 0.921, intercept = + 1.951). OV Monitor serum
levels were low in healthy individuals (n = 267, median = 9.7 kU/L,
95th percentile = 30.8 kU/L), higher in individuals with various
benign diseases (n = 549, medians = 10.9-16.4 kU/L, 95th
percentiles = 44.2-355 kU/L) and even higher in individuals
suffering from various cancers (n = 995, medians= 12.4-445 kU/L;
95th percentiles = 53.4-4664 kU/L). Optimal diagnostic accuracy for
cancer detection against the relevant benign control group by the
OV Monitor was found for ovarian cancer {[}area under the curve
(AUC) 0.898]. Results for the reference CA125 assay were comparable
(AUC 0.899). Conclusions: The Access OV Monitor provides very good
methodological characteristics and demonstrates an excellent
analytical and clinical correlation with Elecsys CA125. The best
diagnostic accuracy for the OV Monitor was found in ovarian cancer.
Our results also suggest a clinical value of the OV Monitor in
other cancers.

Weitere Episoden

Report of the Working Group `Overall Blood Supply Strategy with Regard to Variant Creutzfeldt-Jakob Disease (vCJD)'

Report of the Working Group `Overall Blood Supply Strategy with Regard to Variant Creutzfeldt-Jakob Disease (vCJD)'

vor 17 Jahren
Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial

Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial

vor 17 Jahren
Guidelines for initiation of anti-tumour necrosis factor therapy in rheumatoid arthritis: similarities and differences across Europe.

Guidelines for initiation of anti-tumour necrosis factor therapy in rheumatoid arthritis: similarities and differences across Europe.

vor 17 Jahren
JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.

JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.

vor 17 Jahren
Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.

Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.

vor 17 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„Alternative antibody for the detection of CA125 antigen: a European multicenter study for the evaluation of the analytical and clinical performance of the Access (R) OV Monitor assay on the UniCel (R) Dxl 800 Immunoassay System“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz