podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 15/22 Podcast
  4. CEA, CYFRA 21-1, NSE, and ProGRP in the diagnosis of lung cancer: a multivariate approach
We retrospectively studied the single and combined diagnostic value
of carcinoembryonic antigen (CEA), cytokeratin fragment 19 (CYFRA
21-1), neuron specific enolase (NSE) and pro-gastrin-releasing
peptide (ProGRP), which were routinely analysed in patients with
lung tumours of unknown origin at the time of admission to
hospital. Inclusion criteria were the determination of CEA
(AxSYM/Abbott), CYFRA 21-1 (ElecSys/Roche) and NSE
(Kryptor/Brahms). We examined 1747 patients, where 1325 suffered
from lung cancer (LC; small cell lung cancer, SCLC: n=194;
non-small cell lung cancer, NSCLC: n = 1015; others: n = 116), 318
from benign lung diseases and 104 from lung metastases due to
another primary malignancy. As ProGRP (ELISA ALSI/IBL) became
available only recently, there are less data points of this marker.
In total, 99.8% of LC patients released at least one of the four
biomarkers (defined as values exceeding the median of healthy
controls), and for the discrimination between benign disease (BID)
and malignant lung disease each marker reached 100% tumour
specificity at high levels (CEA: 20 ng/mL; CYFRA 21-1: 40 ng/mL;
NSE: 45 ng/mL; ProGRP: 250 pg/mL). At a specificity of > 99%,
ProGRP reached the highest diagnostic efficacy for SCLC with 57%
true positive results, CEA had the highest capacity (17%) to detect
malignant lung tumours in general and adenocarcinomas of the lung
with 29%. CYFRA 21-1 was dominant for squamous cell carcinomas
(12%). Combining the four markers leads with the prerequisite of
high specificity (> 99%) to 50% true positives for malignant
lung tumours, 44% for NSCLC, 36% for squamous cell carcinomas, 53%
for adenocarcinomas, and 78% for SCLC, respectively. In cases of
lung tumours of unknown origin, the combined use of CEA, CYFRA
21-1, NSE and ProGRP is useful for the differentiation between
benign and primary or secondary malignant disease and suggests the
assignment to histological subtypes.

Weitere Episoden

Report of the Working Group `Overall Blood Supply Strategy with Regard to Variant Creutzfeldt-Jakob Disease (vCJD)'

Report of the Working Group `Overall Blood Supply Strategy with Regard to Variant Creutzfeldt-Jakob Disease (vCJD)'

vor 17 Jahren
Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial

Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial

vor 17 Jahren
Guidelines for initiation of anti-tumour necrosis factor therapy in rheumatoid arthritis: similarities and differences across Europe.

Guidelines for initiation of anti-tumour necrosis factor therapy in rheumatoid arthritis: similarities and differences across Europe.

vor 17 Jahren
JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.

JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.

vor 17 Jahren
Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.

Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.

vor 17 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„CEA, CYFRA 21-1, NSE, and ProGRP in the diagnosis of lung cancer: a multivariate approach“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz