podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 15/22 Podcast
  4. Impact of Gene-Gender Effects of Adrenergic Polymorphisms on Hypothalamic-Pituitary-Adrenal Axis Activity in Depressed Patients
Objective: There is overwhelming evidence that activation of the
hypothalamic-pituitary-adrenal (HPA) system plays a major role in
depression and cardiovascular disease in genetically susceptible
individuals. We hypothesized that due to the multiple interactions
between the sympathetic and the HPA systems via adrenoceptors,
polymorphisms in these genes could have an impact on HPA axis
activity in major depression. Methods: Using the
dexamethasone/corticotrophin-releasing hormone (DEX/CRH) test, we
investigated the association of alpha 2-adrenoceptor (ADRA2A -1291C
-> G) and the beta 2-adrenoceptor gene (ADRB2 Arg16Gly) in 189
patients with major depression during the acute state of the
disease and after remission. Results: Male ADRA2A -1291G allele
homozygotes showed significant pretreatment HPA axis hyperactivity,
with increased adrenocorticotropin (ACTH; F = 4.9, d.f. = 2, p =
0.009) and cortisol responses (F = 6.4, d.f. = 2, p = 0.003). In
contrast, female ADRB2 Arg/Arg homozygotes had increased
pretreatment ACTH (F = 7.17, d.f. = 2, p = 0.001) and cortisol (F =
8.95, d.f. = 2, p = 0.000) levels. Interestingly, in the respective
genotypes, the stress hormones remained elevated in the second
DEX/CRH test, despite a reduction in depressive symptoms.
Conclusions: This study provides evidence that, depending on gender
and polymorphisms, there is continuous HPA axis overdrive in a
proportion of patients irrespective of the status of depression.
Considering the importance of stress hormones for cardiovascular
disorders, our data might suggest that these patients are at high
risk of comorbidity between depression and cardiovascular
disorders. Copyright (c) 2008 S. Karger AG, Basel

Weitere Episoden

Report of the Working Group `Overall Blood Supply Strategy with Regard to Variant Creutzfeldt-Jakob Disease (vCJD)'

Report of the Working Group `Overall Blood Supply Strategy with Regard to Variant Creutzfeldt-Jakob Disease (vCJD)'

vor 17 Jahren
Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial

Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial

vor 17 Jahren
Guidelines for initiation of anti-tumour necrosis factor therapy in rheumatoid arthritis: similarities and differences across Europe.

Guidelines for initiation of anti-tumour necrosis factor therapy in rheumatoid arthritis: similarities and differences across Europe.

vor 17 Jahren
JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.

JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand.

vor 17 Jahren
Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.

Influence of peptidylarginine deiminase type 4 genotype and shared epitope on clinical characteristics and autoantibody profile of rheumatoid arthritis.

vor 17 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„Impact of Gene-Gender Effects of Adrenergic Polymorphisms on Hypothalamic-Pituitary-Adrenal Axis Activity in Depressed Patients“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz