Klinische Studien über die Immobilisation von Mantelpavianen (Papio hamadryas) unter Verwendung der "Hellabrunner Mischung" und über den postnarkotischen Einfluss von Atipamezol und Yohimbin im Vergleich zu Etilefrin als Aufwachbeschleuniger
Beschreibung
vor 20 Jahren
The objective of the present study was to examine the effectiveness
of the anesthetic combination "Hellabrunne mixture" ("HM" =
approximately 125mg xylazine/ml and 100mg ketamine/ml) on hamadryas
baboons, as well as the influence of various drugs over the time it
took the baboons to wake up (their "waking up phase") under
practical conditions. In order to remobilize the baboons,
comparative studies were conducted using: alpha2-specific
antagonists atipamezole and yohimbine as well as the circulation
stimulating drug etilefrine. The "HM" proved to be a very safe and
effective anesthetic, even when given in doses that were too low or
when overdosed. None of the examined animals had any life
threatening incidents. All of the measured physiological parameters
were normal and remained stabile during anesthesia. The three
assayed accelerators used to remobilize the baboons (atipamezole,
yohimbine, etilefrine) showed substantial differences in their
effects. Atipamezole caused the baboons to regain consciousness
significantly faster than the other drugs. However, some of the
animals that were administered atipamezole had catalepsis cramps
during their waking up phase. These side effects can be explained
most likely, by the fact that atipamezole only antagonizes the
xylazine component of the "HM" which causes a relative overdose of
ketamine. Examining the effects of yohimbine administered i.m. (in
contrast to the usual i.v. administration) yielded no substantial
acceleration of remobilization. The same side effects were observed
after administering atipamezole. Similar to atipamezole, etilefrine
also shortened the waking up phase significantly, but to a lesser
extent than atipamezole. In contrast to atipamezole and yohimbine,
no side effects were observed after administering etilefrine. In
summary, the i.m. administration of atipamezole and etilefrine
proved to be suitable to shorten the waking up phase of hamadryas
baboons after using "HM". In contrast, yohimbine cannot be
recommended, as noticeable side effects were evident and no
significant acceleration of remobilization was observed.
of the anesthetic combination "Hellabrunne mixture" ("HM" =
approximately 125mg xylazine/ml and 100mg ketamine/ml) on hamadryas
baboons, as well as the influence of various drugs over the time it
took the baboons to wake up (their "waking up phase") under
practical conditions. In order to remobilize the baboons,
comparative studies were conducted using: alpha2-specific
antagonists atipamezole and yohimbine as well as the circulation
stimulating drug etilefrine. The "HM" proved to be a very safe and
effective anesthetic, even when given in doses that were too low or
when overdosed. None of the examined animals had any life
threatening incidents. All of the measured physiological parameters
were normal and remained stabile during anesthesia. The three
assayed accelerators used to remobilize the baboons (atipamezole,
yohimbine, etilefrine) showed substantial differences in their
effects. Atipamezole caused the baboons to regain consciousness
significantly faster than the other drugs. However, some of the
animals that were administered atipamezole had catalepsis cramps
during their waking up phase. These side effects can be explained
most likely, by the fact that atipamezole only antagonizes the
xylazine component of the "HM" which causes a relative overdose of
ketamine. Examining the effects of yohimbine administered i.m. (in
contrast to the usual i.v. administration) yielded no substantial
acceleration of remobilization. The same side effects were observed
after administering atipamezole. Similar to atipamezole, etilefrine
also shortened the waking up phase significantly, but to a lesser
extent than atipamezole. In contrast to atipamezole and yohimbine,
no side effects were observed after administering etilefrine. In
summary, the i.m. administration of atipamezole and etilefrine
proved to be suitable to shorten the waking up phase of hamadryas
baboons after using "HM". In contrast, yohimbine cannot be
recommended, as noticeable side effects were evident and no
significant acceleration of remobilization was observed.
Weitere Episoden
Kommentare (0)