Paravasation with cyclophosphamide - Case report of tissue necrosis in a patient with primary breast cancer

Background: Paravasation is a rare but severe complication of
treatment with cytotoxic agents. Some anticancer drugs are
considered to be of high toxicity (vesicant), some are merely
irritant, and some are regarded as nearly non-toxic to healthy
tissue as is the case with cyclophosphamide. Case Report: In this
report, we present the first case of severe tissue damage caused by
a paravasation of cyclophosphamide in a breast cancer patient
receiving chemotherapy. Conclusion: Therefore, every attending
oncological physician should be aware of the possibility of severe
tissue damage as a consequence of cyclophosphamide paravasation.