podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 14/22 Podcast
  4. Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus
Background: The pregnancy-specific glycoprotein (Psg) genes encode
proteins of unknown function, and are members of the
carcinoembryonic antigen (Cea) gene family, which is a member of
the immunoglobulin gene (Ig) superfamily. In rodents and primates,
but not in artiodactyls (even-toed ungulates/hoofed mammals), there
have been independent expansions of the Psg gene family, with all
members expressed exclusively in placental trophoblast cells. For
the mouse Psg genes, we sought to determine the genomic
organisation of the locus, the expression profiles of the various
family members, and the evolution of exon structure, to attempt to
reconstruct the evolutionary history of this locus, and to
determine whether expansion of the gene family has been driven by
selection for increased gene dosage, or diversification of
function. Results: We collated the mouse Psg gene sequences
currently in the public genome and expressed-sequence tag (EST)
databases and used systematic BLAST searches to generate complete
sequences for all known mouse Psg genes. We identified a novel
family member, Psg31, which is similar to Psg30 but, uniquely
amongst mouse Psg genes, has a duplicated N1 domain. We also
identified a novel splice variant of Psg16 (bCEA). We show that
Psg24 and Psg30/Psg31 have independently undergone expansion of
N-domain number. By mapping BAC, YAC and cosmid clones we described
two clusters of Psg genes, which we linked and oriented using
fluorescent in situ hybridisation ( FISH). Comparison of our Psg
locus map with the public mouse genome database indicates good
agreement in overall structure and further elucidates gene order.
Expression levels of Psg genes in placentas of different
developmental stages revealed dramatic differences in the
developmental expression profile of individual family members.
Conclusion: We have combined existing information, and provide new
information concerning the evolution of mouse Psg exon
organization, the mouse Psg genomic locus structure, and the
expression patterns of individual Psg genes. This information will
facilitate functional studies of this complex gene family.

Weitere Episoden

External quality assessment of urinary methylmalonic acid quantification - results of a pilot study

External quality assessment of urinary methylmalonic acid quantification - results of a pilot study

vor 19 Jahren
Use of novel serum markers in clinical follow-up of Sertoli-Leydig cell turnours

Use of novel serum markers in clinical follow-up of Sertoli-Leydig cell turnours

vor 19 Jahren
Free serum cortisol: quantification applying equilibrium dialysis or ultrafiltration and an automated immunoassay system

Free serum cortisol: quantification applying equilibrium dialysis or ultrafiltration and an automated immunoassay system

vor 19 Jahren
Die Biegestabprothese: ein experimenteller Ansatz zur metaphysären Hüftendoprothetik

Die Biegestabprothese: ein experimenteller Ansatz zur metaphysären Hüftendoprothetik

vor 19 Jahren
ASCO 2007: What remains important for breast cancer systemic therapy in the routine setting?

ASCO 2007: What remains important for breast cancer systemic therapy in the routine setting?

vor 19 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz