The Role of Bile in the Regulation of Exocrine Pancreatic Secretion

As early as 1926 Mellanby (1) was able to show that introduction of
bile into the duodenum of anesthetized cats produces a copious flow
of pancreatic juice. In conscious dogs, Ivy & Lueth (2)
reported, bile is only a weak stimulant of pancreatic secretion.
Diversion of bile from the duodenum, however, did not influence
pancreatic volume secretion stimulated by a meal (3,4). Moreover,
Thomas & Crider (5) observed that bile not only failed to
stimulate the secretion of pancreatic juice but also abolished the
pancreatic response to intraduodenally administered peptone or
soap.