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Medizin - Open Access LMU - Teil 09/22 Podcast
Comparative chromosome band mapping in primates byin situ suppression hybridization of band specific DNA microlibraries

Comparative chromosome band mapping in primates byin situ suppression hybridization of band specific DNA microlibraries

Medizin - Open Access LMU - Teil 09/22 vor 35 Jahren

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A DNA-library established from microdissected bands 8q23 to 8q24.1
of normal human chromosomes 8 (Lüdecke et al., 1989) was used as a
probe for chromosomal in situ suppression (CISS-) hybridization to
metaphase chromosomes of man and primates including Hylobates lar
and Macaca fuscata. Comparative band mapping as first applied in
this study shows the specific visualization of a single
subchromosomal region in all three species and thus demonstrates
that synteny of the bulk sequences of a specific human chromosome
subregion has been conserved for more than 20 million years.