podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 13/22 Podcast
  4. L-arginine: A unique amino acid for improving depressed wound immune function following hemorrhage
Objective: To determine whether L-arginine has any salutary effects
on wound immune cell function following trauma-hemorrhage.
Background. Depressed wound immune function contributes to an
increased incidence of wound infections following hemorrhage.
Although administration of L-arginine has been shown to restore
depressed cell-mediated immune responses following hemorrhage
potentially by maintaining organ blood flow, it remains unknown
whether Larginine has any salutary effects on the depressed local
immune response at the wound site. Methods: Male mice were
subjected to a midline laparotomy and polyvinyl sponges were
implanted subcutaneously in the abdominal wound prior to hemorrhage
(35 +/- 5 mm Hg for 90 min and resuscitation) or sham operation.
During resuscitation mice received 300 mg/kg body weight L-arginine
or saline (vehicle). Sponges were harvested 24 h thereafter, wound
fluid collected and wound immune cells cultured for 24 h in the
presence of LPS. Pro- (IL-1beta, IL-6) and anti-inflammatory
(IL-10) cytokines were determined in the supernatants and the wound
fluid. In addition, wounds were stained for IL-6
immunohistochemically. In a separate set of animals, skin and
muscle blood flow was determined by microspheres. Results: The
capacity of wound immune cells to release IL-1beta and IL-6 in
vitro was significantly depressed in hemorrhaged mice receiving
vehicle. Administration of L-arginine, however, improved wound
immune cell function. In contrast, in vivo the increased IL-6
release at the wound site was decreased in L-arginine-treated mice
following hemorrhage. Moreover, IL-10 levels were significantly
increased in the wound fluid in hemorrhaged animals receiving
L-arginine compared to vehicle-treated mice. In addition, the
depressed skin and muscle blood flow after hemorrhage was restored
by L-arginine. Conclusions: Thus, L-arginine might improve local
wound cell function by decreasing the inflammatory response at the
wound site. Since L-arginine protected wound immune cell function
this amino acid might represent a novel and useful adjunct to fluid
resuscitation for decreasing wound complications following
hemorrhage. Copyright beta 2002 S. Karger AG, Basel.

Weitere Episoden

HIV-associated multiple intracerebral hemorrhages

HIV-associated multiple intracerebral hemorrhages

vor 21 Jahren
Assessment of potential cardiotoxic side effects of mitoxantrone in patients with multiple sclerosis

Assessment of potential cardiotoxic side effects of mitoxantrone in patients with multiple sclerosis

vor 21 Jahren
Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man

Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man

vor 21 Jahren
Improved ventricular function during inhalation of PGI(2) aerosol partly relies on enhanced myocardial contractility

Improved ventricular function during inhalation of PGI(2) aerosol partly relies on enhanced myocardial contractility

vor 21 Jahren
Behandlungsbezogene Einstellungen und Behandlungsmotivationbei Patienten zweier komplementärmedizinischer Kliniken

Behandlungsbezogene Einstellungen und Behandlungsmotivationbei Patienten zweier komplementärmedizinischer Kliniken

vor 21 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„L-arginine: A unique amino acid for improving depressed wound immune function following hemorrhage“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz