podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 17/22 Podcast
  4. The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease.
The chitinase-like protein YKL-40 was found to be increased in
patients with severe asthma and chronic obstructive pulmonary
disease (COPD), two disease conditions featuring neutrophilic
infiltrates. Based on these studies and a previous report
indicating that neutrophils secrete YKL-40, we hypothesized that
YKL-40 plays a key role in cystic fibrosis (CF) lung disease, a
prototypic neutrophilic disease. The aim of this study was (i) to
analyze YKL-40 levels in human and murine CF lung disease and (ii)
to investigate whether YKL-40 single-nucleotide polymorphisms
(SNPs) modulate CF lung disease severity. YKL-40 protein levels
were quantified in serum and sputum supernatants from CF patients
and control individuals. Levels of the murine homologue BRP-39 were
analyzed in airway fluids from CF-like βENaC-Tg mice. YKL-40SNPs
were analyzed in CF patients. YKL-40 levels were increased in
sputum supernatants and in serum from CF patients compared to
healthy control individuals. Within CF patients, YKL-40 levels were
higher in sputum than in serum. BRP-39 levels were increased in
airways fluids from βENaC-Tg mice compared to wild-type
littermates. In both CF patients and βENaC-Tg mice, YKL-40/BRP-39
airway levels correlated with the severity of pulmonary
obstruction. Two YKL-40 SNPs (rs871799 and rs880633) were found to
modulate age-adjusted lung function in CF patients. YKL-40/BRP-39
levelsare increased in human and murine CF airway fluids, correlate
with pulmonary function and modulate CF lung disease severity
genetically. These findings suggest YKL-40 as a potential biomarker
in CF lung disease.

Weitere Episoden

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis

vor 15 Jahren
Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man

Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man

vor 15 Jahren
Growth Pattern of Untreated Boys with Simple Virilizing Congenital Adrenal Hyperplasia Indicates Relative Androgen Insensitivity during the First Six Months of Life

Growth Pattern of Untreated Boys with Simple Virilizing Congenital Adrenal Hyperplasia Indicates Relative Androgen Insensitivity during the First Six Months of Life

vor 15 Jahren
Growth Patterns in the First Three Years of Life in Children with Classical Congenital Adrenal Hyperplasia Diagnosed by Newborn Screening and Treated with Low Doses of Hydrocortisone

Growth Patterns in the First Three Years of Life in Children with Classical Congenital Adrenal Hyperplasia Diagnosed by Newborn Screening and Treated with Low Doses of Hydrocortisone

vor 15 Jahren
Missing Heritability in the Tails of Quantitative Traits? A Simulation Study on the Impact of Slightly Altered True Genetic Models

Missing Heritability in the Tails of Quantitative Traits? A Simulation Study on the Impact of Slightly Altered True Genetic Models

vor 15 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease.“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Er
Erasmus2

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz