podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 17/22 Podcast
  4. The role of osteopontin (OPN/SPP1) haplotypes in the susceptibility to Crohn's disease.
Osteopontin represents a multifunctional molecule playing a pivotal
role in chronic inflammatory and autoimmune diseases. Its
expression is increased in inflammatory bowel disease (IBD). The
aim of our study was to analyze the association of osteopontin
(OPN/SPP1) gene variants in a large cohort of IBD patients. Genomic
DNA from 2819 Caucasian individuals (n = 841 patients with Crohn's
disease (CD), n = 473 patients with ulcerative colitis (UC), and
n = 1505 healthy unrelated controls) was analyzed for nine OPN SNPs
(rs2728127, rs2853744, rs11730582, rs11739060, rs28357094,
rs4754 = p.Asp80Asp, rs1126616 = p.Ala236Ala, rs1126772 and
rs9138). Considering the important role of osteopontin in
Th17-mediated diseases, we performed analysis for epistasis with
IBD-associated IL23R variants and analyzed serum levels of the Th17
cytokine IL-22. For four OPN SNPs (rs4754, rs1126616, rs1126772 and
rs9138), we observed significantly different distributions between
male and female CD patients. rs4754 was protective in male CD
patients (p = 0.0004, OR = 0.69). None of the other investigated
OPN SNPs was associated with CD or UC susceptibility. However,
several OPN haplotypes showed significant associations with CD
susceptibility. The strongest association was found for a haplotype
consisting of the 8 OPN SNPs
rs2728127-rs2853744-rs11730582-rs11439060-rs28357094-rs112661-rs1126772-rs9138
(omnibus p-value = 2.07×10⁻⁸). Overall, the mean IL-22 secretion in
the combined group of OPN minor allele carriers with CD was
significantly lower than that of CD patients with OPN wildtype
alleles (p = 3.66×10⁻⁵). There was evidence for weak epistasis
between the OPN SNP rs28357094 with the IL23R SNP rs10489629
(p = 4.18×10⁻²) and between OPN SNP rs1126616 and IL23R SNP
rs2201841 (p = 4.18×10⁻²) but none of these associations remained
significant after Bonferroni correction. Our study identified OPN
haplotypes as modifiers of CD susceptibility, while the combined
effects of certain OPN variants may modulate IL-22 secretion.

Weitere Episoden

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis

vor 15 Jahren
Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man

Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man

vor 15 Jahren
Growth Pattern of Untreated Boys with Simple Virilizing Congenital Adrenal Hyperplasia Indicates Relative Androgen Insensitivity during the First Six Months of Life

Growth Pattern of Untreated Boys with Simple Virilizing Congenital Adrenal Hyperplasia Indicates Relative Androgen Insensitivity during the First Six Months of Life

vor 15 Jahren
Growth Patterns in the First Three Years of Life in Children with Classical Congenital Adrenal Hyperplasia Diagnosed by Newborn Screening and Treated with Low Doses of Hydrocortisone

Growth Patterns in the First Three Years of Life in Children with Classical Congenital Adrenal Hyperplasia Diagnosed by Newborn Screening and Treated with Low Doses of Hydrocortisone

vor 15 Jahren
Missing Heritability in the Tails of Quantitative Traits? A Simulation Study on the Impact of Slightly Altered True Genetic Models

Missing Heritability in the Tails of Quantitative Traits? A Simulation Study on the Impact of Slightly Altered True Genetic Models

vor 15 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„The role of osteopontin (OPN/SPP1) haplotypes in the susceptibility to Crohn's disease.“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Er
Erasmus2

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz