podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 17/22 Podcast
  4. Acellular pertussis booster in adolescents induces Th1 and memory CD8+ T cell immune response.
In a number of countries, whole cell pertussis vaccines (wcP) were
replaced by acellular vaccines (aP) due to an improved
reactogenicity profile. Pertussis immunization leads to specific
antibody production with the help of CD4(+) T cells. In earlier
studies in infants and young children, wcP vaccines selectively
induced a Th1 dominated immune response, whereas aP vaccines led to
a Th2 biased response. To obtain data on Th1 or Th2 dominance of
the immune response in adolescents receiving an aP booster
immunization after a wcP or aP primary immunization, we analyzed
the concentration of Th1 (IL-2, TNF-α, INF-γ) and Th2 (IL-4, IL-5,
IL-10) cytokines in supernatants of lymphocyte cultures
specifically stimulated with pertussis antigens. We also
investigated the presence of cytotoxic T cell responses against the
facultative intracellular bacterium Bordetella pertussis by
quantifying pertussis-specific CD8(+) T cell activation following
the aP booster immunization. Here we show that the adolescent aP
booster vaccination predominantly leads to a Th1 immune response
based on IFNgamma secretion upon stimulation with pertussis
antigen, irrespective of a prior whole cell or acellular primary
vaccination. The vaccination also induces an increase in peripheral
CD8(+)CD69(+) activated pertussis-specific memory T cells four
weeks after vaccination. The Th1 bias of this immune response could
play a role for the decreased local reactogenicity of this
adolescent aP booster immunization when compared to the preceding
childhood acellular pertussis booster. Pertussis-specific CD8(+)
memory T cells may contribute to protection against clinical
pertussis.

Weitere Episoden

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis

vor 15 Jahren
Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man

Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man

vor 15 Jahren
Growth Pattern of Untreated Boys with Simple Virilizing Congenital Adrenal Hyperplasia Indicates Relative Androgen Insensitivity during the First Six Months of Life

Growth Pattern of Untreated Boys with Simple Virilizing Congenital Adrenal Hyperplasia Indicates Relative Androgen Insensitivity during the First Six Months of Life

vor 15 Jahren
Growth Patterns in the First Three Years of Life in Children with Classical Congenital Adrenal Hyperplasia Diagnosed by Newborn Screening and Treated with Low Doses of Hydrocortisone

Growth Patterns in the First Three Years of Life in Children with Classical Congenital Adrenal Hyperplasia Diagnosed by Newborn Screening and Treated with Low Doses of Hydrocortisone

vor 15 Jahren
Missing Heritability in the Tails of Quantitative Traits? A Simulation Study on the Impact of Slightly Altered True Genetic Models

Missing Heritability in the Tails of Quantitative Traits? A Simulation Study on the Impact of Slightly Altered True Genetic Models

vor 15 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„Acellular pertussis booster in adolescents induces Th1 and memory CD8+ T cell immune response.“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Er
Erasmus2

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz