podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 17/22 Podcast
  4. A potential role for intragenic miRNAs on their hosts' interactome
Background: miRNAs are small, non-coding RNA molecules that mainly
act as negative regulators of target gene messages. Due to their
regulatory functions, they have lately been implicated in several
diseases, including malignancies. Roughly half of known miRNA genes
are located within previously annotated protein-coding regions
("intragenic miRNAs"). Although a role of intragenic miRNAs as
negative feedback regulators has been speculated, to the best of
our knowledge there have been no conclusive large-scale studies
investigating the relationship between intragenic miRNAs and host
genes and their pathways. Results: miRNA-containing host genes were
three times longer, contained more introns and had longer 5'
introns compared to a randomly sampled gene cohort. These results
are consistent with the observation that more than 60% of intronic
miRNAs are found within the first five 5' introns. Host gene
3'-untranslated regions (3'-UTRs) were 40% longer and contained
significantly more adenylate/uridylate-rich elements (AREs)
compared to a randomly sampled gene cohort. Coincidentally, recent
literature suggests that several components of the miRNA biogenesis
pathway are required for the rapid decay of mRNAs containing AREs.
A high-confidence set of predicted mRNA targets of intragenic
miRNAs also shared many of these features with the host genes.
Approximately 20% of intragenic miRNAs were predicted to target
their host mRNA transcript. Further, KEGG pathway analysis
demonstrated that 22 of the 74 pathways in which host genes were
associated showed significant overrepresentation of proteins
encoded by the mRNA targets of associated intragenic miRNAs.
Conclusions: Our findings suggest that both host genes and
intragenic miRNA targets may potentially be subject to multiple
layers of regulation. Tight regulatory control of these genes is
likely critical for cellular homeostasis and absence of disease. To
this end, we examined the potential for negative feedback loops
between intragenic miRNAs, host genes, and miRNA target genes. We
describe, how higher-order miRNA feedback on hosts' interactomes
may at least in part explain correlation patterns observed between
expression of host genes and intragenic miRNA targets in healthy
and tumor tissue.

Weitere Episoden

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis

vor 15 Jahren
Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man

Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man

vor 15 Jahren
Growth Pattern of Untreated Boys with Simple Virilizing Congenital Adrenal Hyperplasia Indicates Relative Androgen Insensitivity during the First Six Months of Life

Growth Pattern of Untreated Boys with Simple Virilizing Congenital Adrenal Hyperplasia Indicates Relative Androgen Insensitivity during the First Six Months of Life

vor 15 Jahren
Growth Patterns in the First Three Years of Life in Children with Classical Congenital Adrenal Hyperplasia Diagnosed by Newborn Screening and Treated with Low Doses of Hydrocortisone

Growth Patterns in the First Three Years of Life in Children with Classical Congenital Adrenal Hyperplasia Diagnosed by Newborn Screening and Treated with Low Doses of Hydrocortisone

vor 15 Jahren
Missing Heritability in the Tails of Quantitative Traits? A Simulation Study on the Impact of Slightly Altered True Genetic Models

Missing Heritability in the Tails of Quantitative Traits? A Simulation Study on the Impact of Slightly Altered True Genetic Models

vor 15 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„A potential role for intragenic miRNAs on their hosts' interactome“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Er
Erasmus2

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz