podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 13/22 Podcast
  4. Adoptive Immunotherapy in Chimeras with Donor Lymphocytes
Allogeneic stem cell transplantation has a well-defined indication
in the treatment of hematological malignancies. The beneficial
immune effect of allogeneic marrow transplantation has long been
known, but only recently have methods been developed to separate
the graft-versus-leukemia (GVL) effect from graft-versus-host
disease (GVHD). Animal experiments have shown that lymphocytes from
the marrow donor can be transfused without causing severe GVHD if
stable chimerism and tolerance is established. First clinical
studies have been preformed in patients with recurrent chronic
myelogenous leukemia. In these patients complete molecular
remissions were induced that persist without further maintenance
treatment. These results have been confirmed in larger multicenter
studies in Europe and the USA. The best results were obtained in
chronic myelogenous leukemia (CML); repeated successes have been
reported in relapsing acute myeloid leukemia (AML), myelodysplastic
syndromes and multiple myeloma (MMY), and rare responses were
reported for acute lymphoid leukemia. Contrary to animal
experiments GVHD has been observed in human patients although to a
lesser extent than expected in transplants not given
immunosuppression. Secondly myelosuppression has been observed in
patients treated with relapsing CML. In CML the incidence of GVHD
could be reduced by depleting CD8(+) T cells from the donor
lymphocyte concentrate. Alternatively only small numbers of T
lymphocytes can be transfused and in the case of failing responses,
the numbers of donor lymphocytes may be increased. Results in
recurrent AML have been improved by the use of low-dose cytosine
arabinoside, granulocyte-macrophage colony-stimulating factor and
granulocyte colony-stimulating factor mobilized blood cells as
compared to lymphocytes only. In MMY the response rate is higher
than in AML, but the remissions are of limited duration in most
patients. Several protocols have been designed to include
preemptive donor lymphocyte transfusion in patients with a high
relapse risk after transplantation. Problems remain to avoid
chronic GVHD and to circumvent the immune escape mechanisms of
leukemia. Copyright (C) 2003 S. Karger AG, Basel.

Weitere Episoden

HIV-associated multiple intracerebral hemorrhages

HIV-associated multiple intracerebral hemorrhages

vor 21 Jahren
Assessment of potential cardiotoxic side effects of mitoxantrone in patients with multiple sclerosis

Assessment of potential cardiotoxic side effects of mitoxantrone in patients with multiple sclerosis

vor 21 Jahren
Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man

Ischemic preconditioning attenuates portal venous plasma concentrations of purines following warm liver ischemia in man

vor 21 Jahren
Improved ventricular function during inhalation of PGI(2) aerosol partly relies on enhanced myocardial contractility

Improved ventricular function during inhalation of PGI(2) aerosol partly relies on enhanced myocardial contractility

vor 21 Jahren
Behandlungsbezogene Einstellungen und Behandlungsmotivationbei Patienten zweier komplementärmedizinischer Kliniken

Behandlungsbezogene Einstellungen und Behandlungsmotivationbei Patienten zweier komplementärmedizinischer Kliniken

vor 21 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„Adoptive Immunotherapy in Chimeras with Donor Lymphocytes“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz