Vergleich von Alkoholabhängigen mit und ohne Vorgeschichte von Suizidversuchen anhand von klinischen und neurobiologischen Parametern

A serotonergic dysfunction was suggested to be involved into the
biological susceptibility of suicidal behaviour. Tryptophan
hydroxylase (TPH), the rate-limiting enzyme in serotonin
biosynthesis, is a significant regulating factor in the
serotonergic system. Recently the A-6526G, and G-5806T and A-779C
polymorphisms of the TPH 1 gene were identified and suggested to be
associated with suicidal behaviour, but study results are
conflicting. We examined a possible association of the A-6526G, and
G-5806T and A-779C polymorphisms with suicide attempts in a sample
of 80 alcohol-dependent individuals with a history of at least one
suicide attempt. This group was analysed in comparison with 241
alcohol-dependent subjects without such a history. No significant
relationship between haplotype and genotype distribution and allele
frequencies of these polymorphisms with suicide attempts were
detected. Furthermore, no association with number of suicide
attempts and TPH haplotypes were found. Our data do not support the
hypothesis of A-6526G, G-5806T or A-779C polymorphisms to be
associated with suicide attempts in alcohol-dependent individuals.