Impact of glucuronide interferences on therapeutic drug monitoring of posaconazole by tandem mass spectrometry

Background: Posaconazole is a novel antifungal drug for oral
application intended especially for therapy of invasive mycoses.
Due to variable gastrointestinal absorption, adverse side effects,
and suspected drug-drug interactions, therapeutic drug monitoring
(TDM) of posaconazole is recommended. Method: A fast ultra
performance liquid chromatography-tandem mass spectrometry
(UPLC-MS/MS) method for quantification of posaconazole with a
run-time