Einflussfaktoren auf Transplantatüberleben und Transplantatfunktion nach Nierenlebendspende in Abhängigkeit der Sequenz Lebendspende-Kadaverspende versus Kadaverspende-Lebendspende

Since allograft survival is limited after living-related kidney
transplantation (LRKT), the necessity of re-transplantation
following LRKT increases. Information using living-related- versus
deceased donor allografts is sparse. The outcome after kidney
re-transplantation in respect to second graft origin was
investigated. Primary LR- (pLR, n=239), second LR- (sLR, n=26) or
deceased donor following LR transplantations (sDD, n=11) were
compared. Analyses included patient and graft survival, frequency
of rejections, re-surgery, immunological risk and graft function.
Acute rejections, HLA-mismatch and delayed graft function (DGF) and
re-surgery influenced survival. Graft survival following
re-transplantation of living-related and deceased donor grafts is
not necessarily reduced compared to pLRKT. Differences in factors,
impacting graft and patient survival, in particular defining
immunological risk, were balanced in comparisons between the
groups.