Comprehensive bioinformatic analysis of kinesin classification and prediction of structural changes from a closed to an open conformation of the motor domain

Kinesins form a large microtubule-associated motor protein
super-family that can be found in every eukaryotic genome sequenced
so far. Not only is the translocation of a large number of
organelles, protein complexes and mRNAs carried out by them, but
also the formation of the meiotic spindle and mitotic spindle
integrity are strongly dependent on the kinesins. Fourteen
different sub-families of kinesin have been reported. However,
previous analyses were based on a relatively small number of
selected kinesins (