podcast.de
Anmeldung
Anmeldung Registrierung
Auto Hell Dunkel
Erweiterte Suche
  1. Startseite
  2. Podcasts
  3. Medizin - Open Access LMU - Teil 17/22 Podcast
  4. Immediate-Type Hypersensitivity to Succinylated Corticosteroids
Background: Despite their frequent use, systemic corticosteroids
have rarely elicited immediate-type reactions. Objective: We report
two male patients, aged 26 and 70 years, respectively, with severe
immediate-type hypersensitivity secondary to the administration of
corticosteroids esterified with succinate. Methods: Skin tests,
basophil activation tests and challenge tests were performed for
diagnostic evaluation. Results: In both patients, immediate-type
skin test reactions were found to methylprednisolone sodium
hemisuccinate (MSH) and prednisolone sodium hemisuccinate (PSH). In
contrast, nonsuccinylated corticosteroids (including
methylprednisolone and prednisolone in one patient) yielded no test
reactions. Basophils from one patient exhibited a stimulated
expression of the activation marker CD63 upon in vitro incubation
with PSH or hydrocortisone sodium succinate, but not with
hydrocortisone. Skin tests and basophil activation tests were
negative in controls. One patient was challenged with the
incriminated drugs. He developed flush, conjunctivitis, tachycardia
and dyspnea 2 min after injection of MSH, and dyspnea shortly after
intravenous administration of PSH. Oral and intravenous challenge
tests with nonsuccinylated corticosteroids were tolerated well by
both patients. Conclusions: These case reports should alert
clinicians to rare, but severe immediate-type reactions to
corticosteroids, related to the succinate moiety in our patients.
In case of allergic reactions to corticosteroids, it is mandatory
to identify the causative agent and find safe alternatives.
Copyright (C) 2010 S. Karger AG, Basel

Weitere Episoden

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis

Analysis of IL2/IL21 Gene Variants in Cholestatic Liver Diseases Reveals an Association with Primary Sclerosing Cholangitis

vor 15 Jahren
Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man

Biliary Bicarbonate Secretion Constitutes a Protective Mechanism against Bile Acid-Induced Injury in Man

vor 15 Jahren
Growth Pattern of Untreated Boys with Simple Virilizing Congenital Adrenal Hyperplasia Indicates Relative Androgen Insensitivity during the First Six Months of Life

Growth Pattern of Untreated Boys with Simple Virilizing Congenital Adrenal Hyperplasia Indicates Relative Androgen Insensitivity during the First Six Months of Life

vor 15 Jahren
Growth Patterns in the First Three Years of Life in Children with Classical Congenital Adrenal Hyperplasia Diagnosed by Newborn Screening and Treated with Low Doses of Hydrocortisone

Growth Patterns in the First Three Years of Life in Children with Classical Congenital Adrenal Hyperplasia Diagnosed by Newborn Screening and Treated with Low Doses of Hydrocortisone

vor 15 Jahren
Missing Heritability in the Tails of Quantitative Traits? A Simulation Study on the Impact of Slightly Altered True Genetic Models

Missing Heritability in the Tails of Quantitative Traits? A Simulation Study on the Impact of Slightly Altered True Genetic Models

vor 15 Jahren
Alle Episoden anzeigen
In Podcasts werben
Schalte jetzt Werbung in Podcasts.
Episode melden

„Immediate-Type Hypersensitivity to Succinylated Corticosteroids“

Worum geht es? Danach fragen wir noch nach dem Grund.

Abonnenten

Er
Erasmus2

Teilen

Mein Archiv

Deine Privatkopie der Folgen, die du nicht verlieren willst.

Podcast-Folgen verschwinden. Feeds werden auf die letzten Episoden gekürzt, Hoster räumen alte Dateien ab, Formate wechseln den Anbieter und lassen ihr Archiv zurück. Mit „Mein Archiv“ sichert podcast.de die Folgen deiner Podcasts für dich — angefangen bei den ältesten, denn die sind zuerst weg.

  • Deine gesicherten Folgen bleiben hörbar, auch wenn das Original offline geht.
  • Auch Folgen, die im heutigen Feed gar nicht mehr stehen — podcast.de kennt sie noch.
  • Herunterladen bleibt möglich, solange die Folge beim Podcaster liegt. Der zählt seine Abrufe wie bisher.
Startet bald

Sei beim Start von Mein Archiv dabei

Mein Archiv ist fast fertig. Trag dich ein, dann bekommst du eine E-Mail, sobald es losgeht – und bist von Anfang an dabei. Wir schreiben dir nur zum Start, keine Werbung, keine Weitergabe deiner Daten.

Du bekommst zuerst eine Bestätigungsmail. Abmelden geht jederzeit. Datenschutz